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  • Dr. Anu R I

    Precision Oncology & Multi–omics

    Dr. Anu R I

    Email official : dranu@mvrccri.co

    Dr Anu R I is a Cancer Multi-omics specialist and Chemical Pathologist specializing in Cancer Biology, targeted therapy, and translational research. Her primary interest lies in investigating molecular alterations in solid tumors on a multi-omic level. Her research also extends to cancer signaling pathway network analysis, and space biology using data mining and bioinformatics.


    Work Experience

    Dr Anu R I has two PGs from Harvard Medical School to her credit, in High Impact Cancer Research (CBT-HICR) and Clinical Research Training. Anu R I currently works as a Specialist in Precision Oncology and Multi-omics, and Consultant of Clinical Biochemistry at MVR CCRI, India (August 2017- present). She is a member of three Analysis Working Groups- Multi-omics & Systems Biology, ALSDA, and AI for Space by NASA with research project collaborations with them. She pursued MD in Clinical Biochemistry from Safdarjung Hospital, New Delhi, and was awarded First rank with Gold Medal. She has received numerous awards and accolades for experimental research on human genetics. She has delivered lectures on Precision Oncology on various platforms. Her vision encompasses strengthening Precision Oncology in the country and supporting cost-effective diagnostics for all patients with cancer.

    Clinical interest

    • Precision Oncology
    • Cancer Biology and Therapeutics
    • Genetic Counseling
    • Multi-omics: Genomics
    • Epigenomics
    • Transcriptomics
    • Proteomics  and Metabolomics in cancer
    • Bioinformatics enthusiast


    • Disel U, Sivakumar S, Pham T, Fleischmann Z, Anu RI, Sokol ES, Kurzrock R. Increased KRAS G12C Prevalence, High Tumor Mutational Burden, and Specific Mutational Signatures Are Associated With MUTYH Mutations: A Pan-Cancer Analysis. Oncologist. 2023 Aug 17:oyad230. doi: 10.1093/oncolo/oyad230. Epub ahead of print. PMID: 37589222.
    • Ulhaq, Ehsan; Huda, Febin; Suhail, C.; Sheth, Harsh; Anu, R. I. Narrative review on genetic counseling for hereditary cancers: General considerations. Cancer Research, Statistics, and Treatment 6(2):p 239-247, Apr–Jun 2023. | DOI: 10.4103/crst.crst_16_23
    • Citation: Anu RI, Shiu K-K and Khan KH (2023) The immunomodulatory role of IDO1-Kynurenine-NAD™* pathway in switching cold tumor microenvironment in PDAC. Front. Oncol. 13:1142838. doi:10.3389/fonc.2023.1142838
    • The immunomodulatory role of IDO1-Kynurenine-NAD+ pathway in switching cold tumor microenvironment in PDAC
    • Neha Pathak, Anu R I, Padmaj Kulkarni,Amol Patel. A Survey on Unmet Need for Uniform Next-Generation Sequencing Reporting in India. Ind Journal of Med Ped Onc. July 2023.
    • Bhawna Sirohi, Sissmol D, Anu R I, Moushumi S, Shaheena D, Pankaj P, Shona Nag, Arunangshu D, Nitesh Rohtagi, Sanjay Popat, Riyaz Shah, Cherian Thampy, Aparna Raj Parikh, Siddhartha Yadav, Prashant Mehta, Randeep Singj, Deborah Mukherji, Ramila Shilpakar, Sujith Kumar Mullapally, Aju Mathew. Importance of clinical decision making in precision oncology: Discordance in recommendation between next generation sequencing test vendor and molecular tumor board in India. J Clin Oncol 41, 2023 (suppl 16;abstre15050). doi:10.1200/JCO.2023.41.16_suppl.e15050
    • Anu R I., Vatsyayan, A., Damodaran, D. et al. Multi-omics Analysis Classifies Colorectal Cancer into Distinct Methylated Immunogenic and Angiogenic Subtypes Based on Anatomical Laterality. Indian J Surg Oncol (2023). https://doi.org/10.1007/s13193-023-01760-62.
    • Leslie SW, Soon-Sutton TL, Anu R I, Sajjad H, Siref LE. Prostate Cancer. In: StatPearls. Treasure Island (FL): StatPearls Publishing; March 11, 2023.
    • Anu R I, Shamsudeen S, Leslie SW. Prostate Cancer Tissue-Based Biomarkers. [Updated 2022 Dec 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK587345/
    • Anu R I, Aastha V, Ambily S, Dileep D, Kurt van der Speeten. Multi-omic analysis classifies colorectal cancer into distinct angiogenic and immunogenic subtypes based on anatomical laterality [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl): Abstract nr1154
    • Anu R I, Gauri Mittal, Aastha Vatsyayan, Kavita Pandhare, Vinod Scaria. MUSTARD—a comprehensive resource of mutation-specific therapies in cancer. Database, Volume 2021, 2021, baab042. doi.org/10.1093/database/baab0423
    • Anu R I et al. Mutational Signatures, Variant Topography, and Signaling Pathways in Breast Cancer: A futuristic approach to personalized care. Translational Genomics. 2020. doi:10.9777/tg.2020.10001
    • Cash, E., Sephton, S., Woolley, C. et al. The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics. J Exp Clin Cancer Res 40, 119 (2021). https://doi.org/10.1186/s13046-021-01919-5
    • Elbehi AM, Anu R I, Ekine-Afolabi B, Cash E. Emerging role of immune checkpoint inhibitors and predictive biomarkers in head and neck cancers. OralOncol.2020;109:104977. doi.org/10.1016/j.oraloncology.2020.104977
    • Ekine-Afolabi BA, Njan AA, Rotimi SO, R I A, Elbehi AM, Cash E, Adeyeye A. The Impact of Diet on the Involvement of Non-Coding RNAs, Extracellular Vesicles, and Gut Microbiome-Virome in Colorectal Cancer Initiation and Progression. Front Oncol. 2020 Dec 14;10:583372. doi: 10.3389/fonc.2020.583372.
    • The GUaRDIAN Consortium, Vinod Scaria, Sridhar Sivasubbu. Genomics of Rare Genetic diseases-experiences from India. Human Genomics. 2019;13(53)
    • Anu R I, Kaur C, Bhavsar P, Prasad J. Genotyping of Lipoprotein(a) Gene Variants in Coronary Artery Disease in Indian Population. Indian J Med Biochem 2021; 25 (2):76-82.
    • Ajmal Sherif, Anu R I, Prasanth Parameswaran, Sajeevan K V, Sreedharan P S, NKW. When Lung cancer chokes your bowel: an interesting case report. IP International Journal of Medical Pediatrics and Oncology. 2020;6(1) Accepted for publication.
    • Kabi BC, Bhavsar P, Anu RI, Tangdi D, Goswami R, Dudi P. Current Concepts of Vitamin B12 in various disorders: A review. Ind J Med Biochem 2014;18(1):3-13.
    • Tyagi N, Dudi P, Anu R I, Sahoo S S, Ramteke A, Kaur C. Adiponectin gene polymorphisms and Cardiovascular Disease. World Journal of Pharmacy and Pharmaceutical Sciences 2018; 7(2):1-8
    • Tyagi N, Bhadra J, Sahoo S, Anu R I, Bagra P, Kaur C. Adiponectin and IL-10 in Cardiovascular Disease. World Journal of Biomedical and Pharmaceutical Sciences 2018; 5(2):1-4
    • Accepted for Publication

    • Anu R I, Kai-Keen Shiu, Khurum Hayat Khan. The immunomodulatory role of IDO1-Kynurenine-NAD+ pathway in switching cold tumor microenvironment in PDAC. Frontiers in Oncology. 2023
    • Carcinosarcoma Prostate: A Rare Aggressive Type with A Rare Actionable Genomic Variant. Case Report. CRSTonline
    • Genetic counseling for Hereditary cancers: an educational series. CRSTonline


    • MBBS (Govt. Medical College, Kozhikode)
    • MD Biochemistry (VMMC & Safdarjung Hospital, New Delhi)
    • PGC Cancer Biology and Therapeutics: High Impact Cancer Research Program, Special track: Cancer -omics (Harvard Medical School)
    • PGC Introduction to Clinical Research Training (Harvard Medical School)



    The Visionary

    Respectfully called MVR, the late MV Raghavan was one of the revolutionary leaders of the Communist movement in Kerala. Born in an ordinary family in Pappinissery, Kannur, his political life began in his early teens. He served two terms as Minister of Co-operation and Ports in Kerala during 1991-1996 and 2001-2006. MVR revolutionized the co-operative sector by taking the people-powered movement to healthcare and education in the State. MV Raghavan realized the role of the co-operative movement in social development and job creation and he was instrumental in setting up various institutions in the state.